news
lab news
| Sep 25, 2024 | Hannah Anderson published her first first-author paper in American Journal of Physiology-Renal. Her review “Role of Local Angiotensin II Signaling in Bladder Function” evaluates the literature investigating angiotensin II signaling in the bladder. Congrats to all the authors! |
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| Sep 12, 2024 | Our dynamic team at the Medical College of Wisconsin is seeking a post-doctoral researcher to join our group studying mechanisms of bladder sensation, interoception, and pain. The candidate would have the opportunity to lead studies involving signaling between nociceptors and non-neuronal cells in models of interstitial cystitis and bladder pain. They would have the opportunity to learn a variety of techniques from animal behavior, cytometric testing, electrophysiology, fMRI, and optogenetics. Additionally, there are resources available to initiate independent projects with the aim of building an independent research career. Interested applicants can reach out to Aaron Mickle directly through email amickle@mcw.edu. More information about the lab can be found at micklelab.com |
| Sep 01, 2024 | The lab has recently received a notice of award for a new 5-year R01 to study the role of urothelial cells in sensory signaling. With Co-investigators Jim Hokanson and Shahab Vahdat (UC -Riverside), we will start to define a role for the sensory component of urothelial cells in bladder sensation, interoception, and pain. This study will use a recently published animal model that allows us to isolate urothelial stimulation using optogenetics. Congrats to the whole team!  Diagram of the optogenetic model used to study the role of urothelial cells in bladder sensation |
| Jul 01, 2024 | We have arrived and have started establishing the lab and collaberations at MCW!  Medical College of Wisconsin Campus. |
| Jun 01, 2024 | Dr. Mickle was recently interviewed for an article on brain bladder interactions and how urine urgency is perceived. Read Here |
| Apr 29, 2024 | The lab is moving to the Medical College of Wisconsin |
| Apr 25, 2024 | Congratulations to Gabbie Robilotto for winning 2nd best poster presentation for graduate students and Firoj Alom, who won third place in the postdoc category at the annual UF CVM Phi Zeta Research Day. Way to go! |
| Mar 07, 2024 | Congrats to Drs. Firoj Alom and Sabhya Rana on their co-first author publication in eLife! We show evidence that AMPA receptors play a key role in bladder function. Additionally, we show convincingly that AMPA allosteric activators can ameliorate many of the subacute defects in bladder and external urethral sphincter function following SCI, including prolonged voiding intervals and high bladder pressure thresholds for voiding. These valuable results in rodents may help in the development of these agents as therapeutics for humans with SCI-induced bladder dysfunction. |
| Aug 25, 2023 | Dr. Mickle, an assistant professor in the department of Physiological Sciences at the University of Florida College of Veterinary Medicine, has been awarded the 2023 University of Florida Excellence Award for Assistant Professors, a campus-wide achievement and top honor for junior faculty. |
| Jul 11, 2023 | New publication on the communication between sensory neurons and urothelial cells |
| Jun 22, 2023 | Dr. Mickle was recently on the College of Veterinary Medicine Voice Podcast, talking about the lab’s research into new approaches for understanding and treating bladder pain syndrome. Interstitial cystitis/bladder pain syndrome (IC/BPS) affects millions of Americans, and current treatment options are ineffective for many patients. In this podcast, Aaron Mickle Ph.D tells us about his project that aims to determine the role of angiotensin signaling in developing and maintaining disease symptoms of IC/BPS using animal models. These results could open up new FDA- approved treatments with widely available and safe angiotensin inhibitors, substantially impacting patients’ quality of life. Listen Here |
| May 02, 2023 | Firoj Alom, AUA Research Scholar 2022-2024, presented his work on viral transduction of external urethral sphincter at AUA 2024. Congrats Firoj.    Caption photos easily. On the left, Firoj presents his poster. Middle, Firoj is giving an oral presentation. Right, Aaron, speaking at the AUA symposium. Aaron Mickle presented in the Basic Science Symposium “ New Developments in Understanding and Treating Pelvic Pain”. This symposium was highlighted in the AUA Daily News |